Consequently, Cl - efflux occurs upon GABAA receptor activation, leading to depolarization of the postsynaptic membrane and an excitatory effect of GABA
In the case of microvascular disease, some studies relate it to MetS, independent to the presence of T2D [7886], but further studies are needed to ensure these results
Less common but more serious side effects of GLP-1 agonists include: Pancreatitis, an inflammation of the pancreas that causes abdominal pain Gastroparesis, in which the movement of food out of the stomach is slowed or stopped Bowel obstruction, a blockage that keeps food from passing through the intestines Gallstone attacks and bile duct blockage When to See a Doctor About GLP-1 Drug Side Effects Most side effects of GLP-1 drugs are not serious
Curiously, fat-induced OEA synthesis is a fairly conserved pathway in metazoan, being present in fish and extremely slow-metabolism reptiles such as pythons (325, 326)
However, patients should seek urgent medical evaluation for severe or persistent abdominal pain (especially in the right upper quadrant), vomiting, fever, jaundice, or symptoms suggestive of pancreatitis
